Xenopus cadherin-11 restrains cranial neural crest migration and influences neural crest specification
نویسندگان
چکیده
منابع مشابه
Xenopus cadherin-11 restrains cranial neural crest migration and influences neural crest specification.
Cranial neural crest (CNC) cells migrate extensively, typically in a pattern of cell streams. In Xenopus, these cells express the adhesion molecule Xcadherin-11 (Xcad-11) as they begin to emigrate from the neural fold. In order to study the function of this molecule, we have overexpressed wild-type Xcad-11 as well as Xcad-11 mutants with cytoplasmic (deltacXcad-11) or extracellular (deltaeXcad-...
متن کاملExtracellular cleavage of cadherin-11 by ADAM metalloproteases is essential for Xenopus cranial neural crest cell migration.
Cell adhesion molecules such as cadherins alternate their expression throughout cranial neural crest (CNC) development, yet our understanding of the role of these molecules during CNC migration remains incomplete. The "mesenchymal" cadherin-11 is expressed in the CNC during migration yet prevents migration when overexpressed in the embryo, suggesting that a defined level of cadherin-11-mediated...
متن کاملCorrection for Extracellular Cleavage of Cadherin-11 by ADAM Metalloproteases Is Essential for Xenopus Cranial Neural Crest Cell Migration
The authors of Extracellular Cleavage of Cadherin-11 by ADAM Metalloproteases Is Essential for Xenopus Cranial Neural Crest Cell Migration (Mol. Biol. Cell [2009] 20, 78–89; originally published in MBoC In Press as 10.1091/mbc.E08-05-0535) wish to make a correction. The sequences provided in Table 1 (for the morpholino) and Table 2 (for the real-time PCR primers) were truncated in the published...
متن کاملCadherin-11 Mediates Contact Inhibition of Locomotion during Xenopus Neural Crest Cell Migration
Collective cell migration is an essential feature both in embryonic development and cancer progression. The molecular mechanisms of these coordinated directional cell movements still need to be elucidated. The migration of cranial neural crest (CNC) cells during embryogenesis is an excellent model for collective cell migration in vivo. These highly motile and multipotent cells migrate direction...
متن کاملEssential role of AWP1 in neural crest specification in Xenopus.
The neural crest (NC) comprises a transient and multipotent embryonic cell population, which gives rise to a wide variety of cell types, including craniofacial cartilage, melanocytes, and neurons and glia of the peripheral nervous system. The NC is induced by the integrated action of Wnt, FGF, and BMP signaling, and its cell fates are subsequently specified by a genetic cascade of specific tran...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Development
سال: 2001
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.128.16.3049